TREATMENT OF RECURRENT APHTHOUS STOMATITIS WITH COLCHICINE AND ORAL COETICOID

Authors

  • Cuc Nguyen Thi Kim
  • Ghi Dao Huu
  • Thao Pham Thi
  • Luong Vu Huy
  • Thuy Nguyen Thi Thanh
  • Lan Duong Thi

DOI:

https://doi.org/10.56320/tcdlhvn.38.34

Keywords:

recurrent aphthous stomatitis, RAS, colchicin, oral corticosteroid

Abstract

Purpose: To compare the therapeutic effects of colchicine versus oral corticoid in the treatment of recurrent aphthous stomatitis (RAS).

Methods: In an open prospective study, clinical trial, 36 patients with RAS were randomly divided into two groups for treatment with oral corticoid (Group 1), initially at 20 mg methylprednisolone daily in the morning for 1 week, with reduction every 4mg after 2 weeks and group 2: colchicine (1mg daily in the first 4 weeks and 0,5mg daily in the next 4 weeks). All patients were followed-up 8 weeks after treatment and assessed every four weeks. 

Results: Both colchicine and oral corticoid treatments significantly reduced RAS, reducing the number of ulcers, ulcer size, ulcer healing time and pain severity (p <0,01). The response of oral corticosteroids group was better than colchicin at the time of evaluation after 1 week, 4 weeks, 12 weeks and 16 weeks, but this difference was not statistically significant (p>0.05). The difference between the 2 groups was only statistically significant with p<0.05 at the end of treatment. Both drugs were well tolerated. The rate of patients experiencing side effects was quite low (the oral corticosteroid group was 16.7% and the colchicine group was 5.6%).

Conclusion: Both colchicine and oral corticoid significantly reduced RAS and well tolerated. With the regime in the study, the oral corticoid was more effective than colchicine in decrease of the number and size of ulcer, ulcer healing time and pain severity at the end of treatment. The recurrent rate in the two groups was equivalent (p>0,05). 

Author Biographies

Cuc Nguyen Thi Kim

Bệnh viện Da liễu Trung ương

Ghi Dao Huu

Bệnh viện Da liễu Trung ương

Thao Pham Thi

Bệnh viện Da liễu Trung ương

Luong Vu Huy

Bệnh viện Da liễu Trung ương

Thuy Nguyen Thi Thanh

Bệnh viện Da liễu Trung ương

Lan Duong Thi

Bệnh viện Da liễu Trung ương

Published

2023-03-05

How to Cite

Nguyen Thi Kim, C., Dao Huu, G., Pham Thi, T., Vu Huy, L., Nguyen Thi Thanh, T., & Duong Thi, L. (2023). TREATMENT OF RECURRENT APHTHOUS STOMATITIS WITH COLCHICINE AND ORAL COETICOID. Vietnamese Journal of Dermatology and Venereology, (38). https://doi.org/10.56320/tcdlhvn.38.34

Issue

Section

SCIENTIFIC RESEARCH

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