EFFICACY AND SAFETY OF GUSELKUMAB IN THE TREATMENT OF PLAQUE PSORIASIS

Các tác giả

  • Luong T. Dang National Hospital of Dermatology and Venereology
  • Linh T. Trinh National Hospital of Dermatology and Venereology
  • Vinh T.H. Nguyen Hanoi Medical University, National Hospital of Dermatology and Venereology
  • Tuyen T. Nguyen Hanoi Medical University, National Hospital of Dermatology and Venereology
  • Doanh H. Le Hanoi Medical University, National Hospital of Dermatology and Venereology
  • Phuong T. Hoang National Hospital of Dermatology and Venereology

DOI:

https://doi.org/10.56320/tcdlhvn.49.258

Từ khóa:

biologics, psoriasis, guselkumab, IL-23 inhibitor

Tóm tắt

Objectives: To evaluate the efficacy and safety of guselkumab in the treatment of patients with moderate to severe plaque psoriasis.

Materials and methods: A clinical trial was conducted on 32 patients with moderate to severe psoriasis. Patients received subcutaneous injections of guselkumab 100 mg at weeks 0, 4, 12, and 20. Treatment response was evaluated using PASI (Psoriasis Area and Severity Index) and DLQI (Dermatology Life Quality Index). Adverse events were recorded throughout the 20 weeks treatment period.

Results: After 20 weeks of treatment, both PASI and DLQI scores showed a statistically significant reduction. PASI75 and PASI90 response rates were significantly increased from week 4, immediately following the first dose, reaching 93.8% and 71.9%, respectively, at week 20. PASI100 responses were first observed at week 12 and reached 15.6% by week 20. No adverse events were reported in the study population.

Conclusion: Guselkumab demonstrates high efficacy with marginal side effects in the treatment of moderate to severe plaque psoriasis.

Received: September 25, 2024

Reviewed: October 9, 2024

Accepted: December 4, 2024

Online published: 14 September, 2025

Correspondence: Phuong T. Hoang, MD; Email: hoangphuong265@gmail.com

Tải xuống

Đã Xuất bản

19-09-2025 — Cập nhật vào 19-09-2025

Cách trích dẫn

Dang, L. T., Trinh, L. T., Nguyen, V. T., Nguyen, T. T., Le, D. H., & Hoang, P. T. (2025). EFFICACY AND SAFETY OF GUSELKUMAB IN THE TREATMENT OF PLAQUE PSORIASIS. Tạp Chí Da liễu học Việt Nam, (onl2025). https://doi.org/10.56320/tcdlhvn.49.258

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