EFFICACY AND SAFETY OF INTRAVENOUS ILOPROST IN THE TREATMENT OF RAYNAUD’S PHENOMENON AND DIGITAL ULCERS IN PATIENT WITH SYSTEMIC SCLERODERMA

Authors

  • Hoa Nguyen Thi
  • Doanh Le Huu
  • Hien Do Thi Thu
  • Phuong Hoang Thi
  • Thuy Nguyen Thi Thanh

DOI:

https://doi.org/10.56320/tcdlhvn.36.70

Keywords:

Systemic sclerosis, Raynaud phenomenon, Digital ulcers, Iloprost

Abstract

Objectives: To evaluate the efficacy and safety of intravenous iloprost in the treatment of Raynaud’s
phenomenon and digital ulcers in patients with SSc (systemic scleroderma).
Methods: 31 patients with SSc were treated with intravenous iloprost in NHDV from April, 2017 to
March, 2020. Evaluation was done after 2 weeks and included: width of ulcer, depth of ulcer, Raynaud
phenomenon, laboratory tests, drug side effects.
Results: VAS of Raynaud’s syndrome decreased markedly after iloprost infusion, from 71.5 points
to 36.9 points. (p < 0.001). The depth of ulcer improved markedly after 2 weeks of treatment, the rate
of deep ulcers decreased from 20.6% to 1% (p < 0.001). The ulcer width improved significantly after 2
weeks of treatment, the rate of grade 3 ulcers decreased from 35.1% to 13.4% (p < 0.001). Side effects
were found in 38.7% of patients, mainly headache (25.7%), flushing (9.7%); nausea/vomiting (6.5%);
reaction at the site of infusion (6.5%). All side effects disappear when the infusion rate reduced. The
majority of patients tolerated the drug at the maximum infusion rate (level 4), accounted for 61.3%.
Conclusion: Intravenous iloprost is an effective and safe drug in the treatment of Raynaud’s
phenomenon and digital ulcers in patients with SSc. The infusion process should be monitored
according to the instructions.

Received: 12/03/2022
Revised: 21/04/2022
Accepted:  10/05/2022

 

Author Biographies

Hoa Nguyen Thi

National Hospital of Dermatology and Venereology

Doanh Le Huu

National Hospital of Dermatology and Venereology

Hien Do Thi Thu

National Hospital of Dermatology and Venereology

Phuong Hoang Thi

National Hospital of Dermatology and Venereology

Thuy Nguyen Thi Thanh

National Hospital of Dermatology and Venereology

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Published

2023-05-16

How to Cite

Nguyen Thi, H., Le Huu, D., Do Thi Thu, H., Hoang Thi, P., & Nguyen Thi Thanh, T. (2023). EFFICACY AND SAFETY OF INTRAVENOUS ILOPROST IN THE TREATMENT OF RAYNAUD’S PHENOMENON AND DIGITAL ULCERS IN PATIENT WITH SYSTEMIC SCLERODERMA. Vietnamese Journal of Dermatology and Venereology, (36). https://doi.org/10.56320/tcdlhvn.36.70

Issue

Section

SCIENTIFIC RESEARCH

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