TREATMENT OF NAIL PSORIASIS WITH INTRAMATRICIAL METHOTREXATE INJECTIONS

Authors

  • Quang Nguyen Huu
  • Cuc Nguyen Thi
  • Nghi Đinh Hữu
  • Hanh Ngo Thi Hong

DOI:

https://doi.org/10.56320/tcdlhvn.38.36

Keywords:

intramatricial Methotrexat, Nail Psoriasis

Abstract

Objectives: To evaluate the efficacy and safety of intramatricial Methotrexate injections in treatment of nail psoriasis at the National Hospital of Dermatology and Venereology.

Methods: 30 adult psoriasis patients with nail lesions received an intramatricial injection of 1mg methotrexate (MTX) every 4 weeks for 12 weeks. Nail lesions were assessed by using the Nail Psoriasis Severity Index every 4 weeks and after the whole course of treatment. Adverse effects were aslo noted.

Results: After 12 weeks of treatment, the total NAPSI score of the study group decreased from 39.9±17.7 to 14.3±8.9, equivalent to an improvement of 64.1%, the NAPSI score of each nail decreased from 5.7±1.5 to 2.0±0.8 (64.9%) (p<0.01). 100% of patients have improved in which 86.7% of patients have good or fair improvement. No systemic side effects was reported during 12 weeks of treatment, bleeding around the nail matrix was a rare side effect (6.7%) that did not affect the patient's ability to work and daily activities.

Conclusions: Intramatricial methotrexate injections every 4 weeks for 12 weeks is an effective and safe method in treatment of nail psoriasis.

Author Biographies

Quang Nguyen Huu

Bệnh viện Da liễu Trung ương

Cuc Nguyen Thi

Trường Đại học Y Hà Nội

Nghi Đinh Hữu

Bệnh viện Da liễu Trung ương/ Trường Đại học Y Hà Nộ

Hanh Ngo Thi Hong

Trường Đại học Y Hà Nội

Published

2023-03-05

How to Cite

Nguyen Huu, Q., Nguyen Thi, C., Đinh Hữu, N., & Ngo Thi Hong, H. (2023). TREATMENT OF NAIL PSORIASIS WITH INTRAMATRICIAL METHOTREXATE INJECTIONS. Vietnamese Journal of Dermatology and Venereology, (38). https://doi.org/10.56320/tcdlhvn.38.36

Issue

Section

SCIENTIFIC RESEARCH

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