FREQUENCY OF THE SINGLE NUCLEOTIDE POLYMORPHISM RS743572 VARIANT OF CYP17A1 GENE AND ITS ASSOCIATION WITH ACNE SEVERITY IN VIETNAMESE PATIENTS

Abstract

Objective: To determine the frequency of the rs743572 variant of the CYP17A1 gene and its association with clinical characteristics in patients diagnosed with acne.

Materials and methods: A cross-sectional study was conducted on Vietnamese patients diagnosed with acne from March 2023 to July 2023 at Ho Chi Minh City Hospital of Dermatology and Venereology. The variant was identified using Sanger sequencing.

Results: A total of 95 Vietnamese patients were diagnosed with acne. The majority were aged 12-25 (84.2%), with a median age of 21 years (ranging from 12 to 43 years), and 60.0% were female. The allele frequencies were 43.2% for allele A and 56.8% for allele G. The genotype distribution was 16.8% AA, 52.6% AG, and 30.6% GG. A statistically significant association was found between the presence of the variant and the clinical severity of the disease.

Conclusion: This is the first study to determine the rate of the rs743572 variant in a Vietnamese acne population, initially noting a statistically significant association between the variant and disease severity.

Received: 14 October 2023
Revised: 19 July 2024
Accepted: 30 August 2024